Astressin-B Research report – Norma – Parcel A
Jason Wats MD 
Right on time here is an update on project’s ongoing progress;
Currently we have 3 distinct sub-groups in Parcel A that are being given different dosage of the compound, while they are responding to the treatment, the impact is significantly different. As the dose decreases the results also decrease. There is no substantial difference between the mid-level group and the group that is taking the highest dosage.
In regards to the highest group, 91% of the subjects have showed full recovery, which means they the hair count is a par to the isolated control group. 8% of the remaining subjects are showing significant regrowth, while 1% is showing moderate regrowth.
In the mid-level group 85% of the subjects have showed full recovery, 13% demonstrate significant regrowth, 2% are showing moderate regrowth.
In the lower dosage group 31% of the subjects have showed full recovery, 10% of the remaining subjects demonstrate significant regrowth, 41% are showing moderate regrowth, and 8% of the subjects did not show any signs of regrowth at all.
An interesting side note is that every subject suffering from Cushing’s syndrome has showed full recovery, regardless of the dosage that it was given, we will elaborate more on this in the next report.
Within Parcel B there are 5 sub-groups, each being given the same dosage of the compound. These groups have been divided CRF levels. We cannot get into specific results about this parcel since we are yet to process all of the data.
I asked Sarah to post a complementary report on Parcel B and C this week, she will also be covering the following issues; Cortisol levels, Why this experiment is relevant of Androgenic Alopecia patients and side effects, so stay tuned.
p.s. you might have noticed the name “Norma” in the title of the post, it is the internal “code” we have given to our research project, a mere triviality to most, but significant to us since it is a tribute to someone very dear to our team that passed away last year.
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Awesome update you guys! Looking forward to the other posts this week. Especially the relevancy to AA and side effects. Keep up the amazing work! God Bless!
Also, can I ask what the dosages were that you all are testing for the high, mid-level, and lower level? Also, if the mice weigh different amounts do you adjust the % of astressin-b they receive according to weight? Very curious! : )
Jason,
What are the three different dosages being administered to the separate groups of mice?
Steve
This is Awesome.I am so happy to hear this.
Keep going ..!!!!!!! God bless you guys
Thank You very much for the update. You guys at Hairloss Research are the only source I use to keep updated on the latest information. Your efforts are much appreciated!
Has any other drug ever produced results like these on mice? Also, is it known yet whether astressin-b is acting directly on the follicles or if its affecting something else in the body which is in turn returning the hair condition to normal? do the mice seem less stressed? Thanks for all your work, this is all very interesting, at the least.
I jus wet me pants after reading dis
Any chance u guys try this on a bald homeless man to see if it works on Homo Erectus- I could drop a 12 pack off which is all those guys want in return.
goooooo on please some info on expected dose for rat (or human )
I think comments might need to be disabled.
> Any chance u guys try this on a bald homeless man to see if it works on Homo Erectus- I could
> drop a 12 pack off which is all those guys want in return.
LOL!
Well we do need a human subject. Hell I’d volunteer if I could. Almost certainly you’d have to take these trials overseas as getting through the wall of FDA beaurocracy will take a lifetime. Start looking into contacting companies doing clinical trials overseas please. You’re our only hope as research into the area of AA is comatose.
Keep up the good work.
Fred, unfortunately your statement is not too far from what we predict will be the outcome. It’s a shame when “regulation” (or the lack there of) prevents advancements in medicine and technology that could be developed in our own country.
Hello Vieira, there have been plenty of compounds in the past that have produced great results on mice that did not translate into the Human trials. However astressin-b is different, and I have asked Jason to explain in a separate post why we feel this will be a “game changer”.
The compound is affecting multiple organs in different ways. Most people have no idea of the impact that stress has in the body, particularly our Cortisol levels.
Thank you Arul, your words mean a lot to us.
I’m reading with great interest, as I have alopecia areata… I’m also living in Europe. Is there a history of faster approval for such treatements outside the USA.
Best of luck with your research.
I am interested in hearing the answers to Kenny’s and Steve’s questions.
Sarah, please can you give Jason a nudge on this explanation why Astressin B will be different to other compunds used to grow hair on mice ?
Thanks
Is there any reason why this couldn’t be made into a oral supplement?
It has to travel directly through the blood stream.
Helloo Sarah,
Can you tell us when we can buy Asstresin B. And where?
Greeting
Hi everyone! Firstly I want to say this web it’s absolutly awesome!!! I encourage you to keep on with astressin-b and all your posts (helping me and a lot of people).
Sarah, since you talked about cortisol levels and how important they’re for our organism I’ve been trying to get some information and I found a plant which seems to regulate this cortisols levels. It’s called rodhiola rosea. Whats your opinion of this? Thanks a lot!. From Spain, Oriol,
Parcel b please and any side effects?
And can you state the dosages please.
I’d just like to echo 2 of these posts….
1) i’d love to hear about Parcels B & C
2) is it possible that Astressin-B could be sold as a supplement (once safety has been established in a human trial) rather than going through the FDAs whole “new drug” 3-phase rigamarole?
thanks so much to you — Sarah, Jason — and the rest of your team
Parcel B and C and update to why this is important to AA Please! The suspense is killing me!
Suspense is killing me too!!!
Why is it important for AA and what are the side effects?!?
Ahhhh.
This treatment will work for androgenetic baldness?
Finally science realized MPB may have something to do with high cortisol levels and the stress response.
I have always claimed this because in my case I had thick full of hair with no sign of hair loss up until I did South Beach diet at age 27. I know fad diets cause temporary hair loss but this was not temporary. I wish it was. I later learned South Beach diet , another low carb diet, causes so much stress to the body that cortisol levels may double or more in some poeple. I guess that’s what happened with me. It kick started my hair loss which still continues to date and I am 34 yrs now with frontal diffuse hair loss. I’ve been posting on hair sites that especially frontal diffuse hair loss has something to do with stress response, that is physical or mental stress. Nobody believed me and most brushed it off by the typical “it is all DHT” responses Now finally science is on the same page. I wish I could get my hands on this treatment because I know it would work for me. Pitty we have to wait years before it is out there.
I took an oral dose of Astressin- C and I had positve results but only grew a middle leg
Scoobie:and you made a game of hand from wrist, to minimize the effects of middle leg?
You are wooden foot massage
Hello everyone, we apologize for the unusual delay in our feedback, things should get back to normal as the week progresses.
JM: Thank you for your support. The EMA (European Medicines Agency) has a reputation of having a more expedite drug approval process, but in reality it’s nothing but an illusion: http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM247470.pdf
Sam: I am sorry Sam, at this moment we will not be releasing dosage specifications.
Yul Brynner: I will indeed. I can tell you that it targets one of the main factors that leads to hair-loss, cortisol. The compound is proving to have other positive interactions.
kees: Unfortunately it’s early to say, first and foremost you will not be buying Astressin-B, you will be buying a treatment where Astressin-B is the prevalent compound.
Oriol: Thank you, we truly appreciate your kind words. Rodhiola rosea is used in cases where people are not producing enough Cortisol, this is not usually the case in Hair Loss Patients, as a matter of fact quite the opposite, do get in touch with us in case you need more information on this matter.
John: Hopefully until the week is over I should be able to write a post on the other Parcels.
Jacob: 1. Soon. 2. Great question, while it’s not entirely impossible, I sincerely doubt it, most likely we will be looking at an Intravenous therapy.
TaK and JTS : Shouldn’t be long now.
SIO: everything is pointing to that direction so far.
IS DGN: I loved your post for several reasons, the main one being that I have treated numerous patients that had abnormal cortisol levels due to having gone on low carb diet. I am going to write a post on this subject, thank you for the inspiration.
You said in the parcel A, 91% of subjects have experienced full recovery. What does exactly mean recovery? regrouwth??
It seems this treatment works in what you are foccusing your investigations, and with no side effects, so that, it seems your investigations are going to success. If so, when are you expecting to launch the stuff into the market? And which will be the mechanism for the application? (topical, Impfug, oral,….)
Thanks for the previous, and accurated answers
Was just stated that it will more than likely be intravenous. They don’t know how long it has to go through FDA trials. They haven’t posted about side effects yet.
Ok cortisol anti inflamatory i think I’ve heard enough. Body attacks the hair thinking is foreign. Asstressin will cure AA among other things.
Only question is now when is going to be released.
Cortisol increases with age. That’s AA again.
I think we’ve found the culprit here.
for anyone interested:
http://www.ncbi.nlm.nih.gov/pubmed/8003325
“Our findings showed a significant elevation of F [cortisol] in both male and female AH patients compared to controls, pointing to the suprarenes as a contributing factor in AH. This is confirmed by the observation of exacerbated AH in periods of increased stress”
Very interesting Jacob thanks for sharing! I’m so glad this is so close to being a breakthrough!
To what extent does Astressin-b drop cortisol levels in the murine model? I know for mice over-expressing cortisol or mice with cushings syndrome cortisol is pretty much always too high but if this was used for people with MPB who had somewhat average cortisol levels would it drop their levels too low? Levels too low are also detrimental as you know already, so my question is basically does this lower systemic cortisol levels significantly, and could that be dangerous?
Sarah, I have 22 years and I’m hard losing hair, my scalp have alot oil, the astressin can help me in future?
Ace Ventura: Recovery is more than hair regrowth, the skin pigmentation was also improved as well as other positive methabolic changes.
Jacob: Thank you for posting that article.
Sam: That’s a fantastic question. In reality the problem does not rely solely on the cortisol level itself, but also how it is interacting with the organism. This means that subject A might have the same Cortisol measurement as Subject B, but completely different systemic metabolic reactions.
Sam we are really appreciating your interventions, they are bringing a lot of depth to our community discussions.
Would also like to thank everyone else for participating, the level of interest that our project is attracting helps keep our team motivated and focused.
As Sarah correctly stated, each organism is different, and rushing into conclusions/assumptions based on base level averaging is not a good idea, as a matter of fact this is why many treatments fail.
There is a reason why we feel that a future treatment based on this compound will be adjusted to each individual needs, and why we speculate that it might be administered intravenously.
Roxton: we believe so.
Hi Sarah,
Would you please tell us when you honestly feel your product will be available to the consumer? I know it is early, however a ball park honest guess would suffice!:) Thank you
Hello Allan, we are not producing a product, we are merely a research group. We will however, support and work with a private initiative that intends to release a product based on this compound.
Ok, I see. Basically to my understanding sarah you and your peers continue to research this compound and are awaiting an actual company to purchase the rights to the compound so that they can start testing it themselves and EVENTUALLY THEIR PRODUCT will potentially hit the shelves years down the road. Please correct me if im wrong, thank you and please know im not by any means trying to be a pessimist. Thank you
Thanks for the responses, I’m very interested in actually pursuing a career in Biology and I want to put some of my studies into neuroscience, especially as someone who has suffered from chronic anxiety and stress, I would like to further understand the HPA axis and the intricacies of CRF and Cortisol on the human body. My question to you guys is, and although I am not a molecular biologist, I do know that the sequence for the astressin-b peptide is complex and costly, how would this be made into massive amounts for humans? I speculate humans will need a much higher dose than mice, even in this report you saw an increase in hair growth with higher doses than the low ones but also it’s hard to tell even with a long-acting peptide like Astressin-b if the temporary blockade of CRF would result in human hair regrowth or if humans would need to take a much higher amount of it for a longer period of time to see the same results. Do you guys speculate that humans will be able to take the same type of 5 injections over 5 days cycle and see regrowth or do you think it will be much more intricate, will humans have to take a shot once a week of a higher dose over a few months. Also, finally I would like to ask if you see this as the end-all cure for people with Cushings syndrome because if it is or could be that is truly wonderful. Thank you for your research.
Sarah,
Quick question…
it seems that with the mice, the effects were quick and lasted a long period of time.
I’ve read some stuff recently that got me thinking… do you think they will like regulate the dosage of astressin-b to where it’s lower so in order for it to work patients will have to take it often, like weekly or monthly or something as opposed to getting one shot that restores hair for years? You know… in order to make more money off of it, because we all know they’d rather have people buying medication as often as possible then give people actual cures for problems. What do you think?
Sarah,
I really want this to work for hairloss as my hair is waving bye-bye
as we speak. But I was wondering if this will help diabetes and other
illnesses in any way?
first of all i want to apologize for my english.
Sarah can you tell us,in your opinion IF all the phases gone Perfect(i said IF)when do you think it will be released to the market.i think its important for people who think to get a hair transplant.I’d like to thank you in advance…!!
^what xaris said.
i’d go anywhere in the world for an injection if it works.
if there’s no complications would we be able to get injections somewhere else around the world anytime soon? We all know the FDA will take years before we can get it in america. If it works and is safe there’s gotta be somewhere else we can obtain it in the near future!….right?
timallen45: Exactly tim, would would not mind being part of the early development process,but we do not want to be connected with any specific private company.
Sam : Another wonderful post, thank you. I pinged Jason to reply to most of your questions, but I can tell you that I doubt that the treatment will have such a short span between the injections. Also the results wont be as quick as we are verifying in our current tests, but they will surely be as effective in a long run, Jason will give you a more detailed feedback as soon as he can.
JTS : I’m not exactly known for being very PC, I have to say it’s a possibility, these companies are not exactly out there to find cures..the problem is.. if one drug companies releases a treatment that clearly works, and presents long terms results, others will have to follow.
Astressin-b would be a treament for alot of disease ,,,let’s say that you are helping people to get info about this miracle ,,,thyroid autoimmune disease hair loss chronic fatigue irritable bowel anxiety palpitations ,,,all these are always found in same time in some persons that are caused by this heavy and unusual reaction to stress in some people once you go inside this circle you wouldn’t get out for whole life ,,,i know well that in medicine when you break the circle many things may impove in correlation ,,, dreams never stop ,,,but please we need to try by any way to find way that this be available within year not more ,,, please continue your work and promise us to tell us the shortest way to get this and be a real life changing treament in life of millions ,,thanks heros
Dr.Ahmed Dawoud
Yes, please help us.
What is the relation of cortisol to Alzheimer disease if any?
You guys are doing a great job but when will the human trials begin?
I cant wait for this to be a success, its tragic how hairloss effects self-esteem. You guys really need to get this thing out fast. Please guys.
Hello,
Do you foresee the injection being administered into the scalp, or into the Median cubital vein upon human trials?
Thank you very much
Thanks for your responses. According to your study results, the mice suffering from Cushings syndrome showed a full recovery. For humans with Cushings, could this be the end-all cure? Even if it was implemented through IV therapy how much of this peptide would you anticipate would be needed and at what amount. I actually read through a bit of the patent and they had a lot of information about what they would do to test humans but I would like to hear from researchers what you guys think or what you would estimate as the adequate human dose and how often if you are allowed to answer such a question. Finally, I would like to say thank you for answering not only mine but other peoples posts, these kinds of discourses are very important for the progression of science and I say on behalf of myself and I think on behalf of many others thank you for your work and effort.
I’m starting to get nervous…
Why are we no longer hearing/talking about this anywhere?
It seems like this is a REVOLUTIONARY ‘cure’ that is incredibly effective and quick without any serious side effects? Furthermore, it seems relatively easy and cheap – all you need is the injection of a peptide. I’ve seen various places online where people have found chemists that can produce the compound without difficulty or much cost. I just don’t see how there hasn’t been anyone to try this out yet! This could change peoples lives so easily! I just don’t understand why it would take so long if it is so great, easy and safe as it seems to be! I understand the FDA is rigorous but still, I don’t see why someone somewhere in the world hasn’t heard of how revolutionary it could be and experimented with it or offered it? Or why can’t someone offer it here without FDA approval, I know tons of people who’d be willing to sign off! I by no means mean to be pessimistic, I just feel like we essentially have a life changer and it’s just sitting there!… Please don’t tell me this is another treatment that is for some reason still YEARS away from being available in any way……
Hello, first of all I want to know why no man did yet tested this product?
I think the product should not be difficult to obtain, if man tries could change the lives of many people even before the FDA does not validate the product, Why wait years?
Let’s set our fate now instead of waiting years and be disappointed later!
I’m sure this product could change the lives of many people!
If we wait for every test we should wait for years, then try this treatment and it will be fixed like that!
I do not understand that people have tried the treatment on him?
You guys are asking why isn’t it moving along faster? That’s easy, it’s because the people that dicovered it have probably patented it or tinkering with it until a billion dollar company comes along and buys it….at that point they will begin their own testing and yep what do you know all of a sudden a once promising treatment turns into a possible treatment that is several years away from POTENTIALLY coming to market.
Ahmed dawoud: thank for the kind words, but we are just scientists, far from heroes.
karthik India: thank you. Unfortunately I cannot speculate on the effects of the compound on other diseases other than the ones we are focusing at this moment. We have no information regarding the Human trials, but we will be able to provide more info as the experiment progresses.
Hello Sam, I completely agree with you, debate is an essential part of progress, and I think that most scientists don’t realize how important it is.
I wouldn’t go as far as calling it a cure so far, since we are still studying how the subjects react to the interruption of the treatment. At the moment we are treating the compound as a potential treatment.
This product is already available from DS labs as astressin-b tropical solution
[...] Subject CRF levels were also manipulated in order to replicate specific conditions. Data Parcel A Parcel A.A: 99% of the subjects are showing full regrowth, while 1% a significant results. Mild [...]
Salut Sarah, je suis religieusement tout vos updates mais jai quelques difficultés a comprendre si vos les resultats sont positif et si je vais retrouver un jour mes cheveux. Je pense a vous tout les jours et vous envoies de lenergie positive pour vous appuyer dans vos recherches.